Thanks Proteusx for you suggestions. I too was recently prescribed NB-N5 by my pain doctor. But couldn't get any good answers as to the amount of research that's been done on this. They want a $150.00 for (I think) a 3 month supply. I currently take a B12 and Magnesium Glycinate, in addition to a 150mg Lyrica tablet a day. That's been keeping my PN in check fairly well, although some nights are still tough. So, I just looked up your recommendations for, as you say "B12, alpha lipoic acid, vitamin D, methylfolate and vitamin D3 individually from well known brands,..." and found that there is quite a wide variety of dosages and brands, associated with varying pricing (which altogether would actually add up to close to what EBM are asking for their NB-N5 product). Based on that I have a follow up question, if you'd be so kind. Could you recommend specific dosages of the above, so as to allow me to be more precise in my research? That would be super helpful. Thanks