@krisrwalters I included this in my post:

'There are certainly instances where overmedication may happen, or truly intolerable side effects,'

I just want to provide a balancing viewpoint because there are so many posts online about side effects and I have friends who are so scared that they won't try them. Apologies for stating the concern so strongly.

It sound truly scary to be dependent on hormones , for comfort, that are also potentially feeding a cancer. I hope you can get off gently but quickly. You are in the opposite direction of AI's- more estrogen rather than less. I hope there is a pain mgmt. doc or alternative doc or some doc who can help.

I have systemic lupus, high scleroderma tests, atrial fibrillation, COPD, spinal cord damage, 7 spinal fractures and am extremely sensitive to meds, foods and the environment. Recently I was told it was probably eosinophilic esophagitis. My daughter has shown a lot of the signs of EDS: very loose joins, POTS/fainting, along with type 1 diabetes and epilepsy. It's not like we are the health privileged here.

So many people avoid AI's. I think it is worth it to try. Exercise helps. But I get- and I included in my post- that for some it is simply intolerable to eliminate detectable estrogen. Oncotype may also show low risk.

Because of my lupus, my doc did not want me to do radiation. That is one reason I had two mastectomies.

As for cancer spreading with parenchyma as a factor, that is very interesting. My docs told me that we all have cancer cells floating around, and that with cancer itself there are some cells that "want to go somewhere." It was explained to me that that is why my lymphovascular invasion was a concern, as would positive nodes. It's not like the cells from my LVI were going to crawl upward: it's that they demonstrated the ability to move and implant and not all cancer cells do. That was back in 2015 so it is good to read some theories about other factors.