1. < Prostate Cancer

Vitamin D intake and PSA reduction

Posted by desertfalcon1954 @desertfalcon1954, Mar 7 8:17pm

I have read a medical study in which they said a 40000 IU of Vitamin D daily intake for 10 weeks reduced PSA substantially.
Can anyone here elaborate on this please

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kujhawk1978 | @kujhawk1978 | Mar 9 10:03am

I am not sure what to say...

Over my ten years with PCa, I have seen a lot of literature, I did not say research, about various causes of PCa and treatments outside of the normal radiation, surgery, chemotherapy.

Some of that literature talks about causes such as processed meats, dairy, height...

Some of that literature talks abut supplements role in treatment...Vitamin D, Calcium, Magnesium,...

At the end of the day, my takeaway from that literature is our lifestyle - diet, exercise ,managing stress, can play a role in several ways:

Better enabling us to be in condition to go through treatment.
Mitigating the side effects of treatment.
Improving our recovery from treatment once we stop (if we do for other than hospice!)

I see my primary care doctor annually for my physical, he does an extensive set of labs including the standard CBC, Metabolic, Lipid...we stay on top of diagnostic preventive tests such as colonoscopy, heart calcium tests..., I see my cardiologist annually, same for my optometrist...if I sense something is off between those annual visits, set up a consultation to discuss with them.

The labs my primary care doctor orders do include checking for various things such as Vitamin D, Calcium, Magnesium...if those results come in outside of established ranges, he and I are prepared to discuss supplements, they haven't, we don't....

The two times I have been on ADT, first time 18 months, now 12 months, my urologist has recommended I add a Vitamin D supplement to my daily list of medications, I followed his recommendations. In both cases he ordered a baseline bone density scan and then a post ADT one. In each case, he said I was fine to stop the Vitamin D supplement when I completed ADT based on lab results and the bone density scan.

I have browsed through the various links others have posted, I don't see anything I am willing to hang my hat on as "treatment" to lower my PSA.

Kevin

REPLY
kjacko | @kjacko | Mar 9 10:43am
In reply to @handera "The two clinical trials, cited in your clip, can be found at these websites: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387395/ (April..." + (show)
@handera

The two clinical trials, cited in your clip, can be found at these websites:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387395/ (April 2012)
This trial included 44 participants who took 4000 IU of Vitamin D daily for 1 year.
Results:
"No significant changes in PSA levels were observed. However, 24 of 44 subjects (55%) showed a decrease in the number of positive cores or decrease in Gleason score; five subjects (11%) showed no change; 15 subjects (34%) showed an increase in the number of positive cores or Gleason score."

https://academic.oup.com/jcem/article/98/4/1498/2536841? (May 2013)
This trial involved 66 PCa patients scheduled to undergo radical prostatectomy. They were randomly placed into three groups and given vitamin D orally, once per day, for 3 to 8 weeks, up to the day before their RP surgery.
1) 400 IU (10 μg)
2) 10 000 IU (250 μg)
3) 40 000 IU (1000 μg).
Results:
- Groups 2) & 3) had lower blood serum levels of parathyroid hormone (PTH is a measure of PCa bone metastases) and PSA (see baseline/final chart attached).
- "In conclusion, our clinical trial data support the hypothesis that prostatic in vivo vitamin D metabolism can be modulated by high oral vitamin D dosing. Furthermore, the decrease in Ki67 labeling and modest declines in serum PSA and PTH with higher prostate calcitriol achieved with vitamin D doses (10 000 and 40 000 IU/d) suggest a potential clinical benefit. Lastly, the vitamin D doses (400–40 000 IU/d) were well tolerated by PCa patients without signs of toxicity."

Years ago I was found to have a Vitamin D deficiency. I currently take a 5000 IU Vitamin D softgel capsule daily, maybe I should increase that to 10,000 IU/day???

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When mine was low my doctor put me on a 50000 dose once a week for 10 weeks. After that my D level was 78, well above the level needed. He said it was safe to be at 100. I take 5000 daily. Good luck.

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handera | @handera | Mar 9 2:29pm
In reply to @desertfalcon1954 "No. It was published here but thank you for adding more information about the subject. https://bmjopen.bmj.com/content/bmjopen/11/3/e044055.full.pdf" + (show)
@desertfalcon1954

No. It was published here but thank you for adding more information about the subject.
https://bmjopen.bmj.com/content/bmjopen/11/3/e044055.full.pdf

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Thanks for the clarification as to this May 2021 publication where the two referenced earlier trials, summarized above, are mentioned.

This ProsD study is a double-blinded placebo-controlled phase II randomized control trial and appears quite rigorous. It’s also using a huge initial dose of Vit D (500,000 IU), based on a protocol used in a different trial with melanoma patients.

The authors refer to evidence and a mechanism by which high levels of Vit D may prevent genome DNA damage.

I’ll be interested to read of the results.

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gently | @gently | Mar 10 4:07pm
In reply to @dang6394 "What about increased calcium in your blood?" + (show)
@dang6394

What about increased calcium in your blood?

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D3 increases calcium absorption in the intestine, less for the kidneys more for the serum.

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