I just added a response to this thread but couldn't find this reply that I wanted to respond to: I see two different variations of this post.

Anyway, I apologize for taking so long to respond but I did want to say that the nodules, even when small, can be tested for biomarkers via a bronchoscopy. My nodules had to be tested for mutations to identify the EGFR (and other) mutations; they couldn't use the analysis from the growths removed in the lobectomies, because there's no guarantee the mutations are the same (and I did have a variety of mutations). An interventional pulmonologist can get samples of nodules if the nodules are large enough. Actually, "large enough" doesn't have to be terribly large if the pulmnologist is very good. My pulmonologist took "samples of two subpleural nodules positive for adenocarcinoma (0.5 cm each)" that were large enough for full molecular analysis.

Do talk to a pulmonologist about whether the nodules are large enough for sampling. If they aren't now, they will be soon unless of course they are very indolent, in which case you don't yet need their molecular analysis.