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Anyone else have CHEK2 gene mutation? And have had multiple cancers?

Cancer | Last Active: Mar 11 10:27am | Replies (51)
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@gigi2016

@colorado77 and @californiazebra
I am 53 and I have CHEK2 mutation and was diagnosed with stage 1 ILBC and today I had my 4 colonoscopy and a 10mm sessile polyp was removed. My father died at the age of 48 from stomach cancer. Based on my CHEK2 mutation results, I am a high risk for BC, colon, cervical, endometrial, ovarian, thyroid, kidney cancer. I had a hysterectomy last year but my ovaries were left. So far I have experienced 1 of the many listed and I pray that my biopsy results is negative. Although I do wonder about what I should do if my biopsy is positive. My middle sister had anal cancer and completed chemo and radiation in 2023. My oldest son has tested for CHEK2 and was negative but I am waiting on my youngest son to test. I pray that God takes care of everyone on this forum and brings peace upon your souls as well as your loved ones🥰

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Zebra | @californiazebra | Mar 9 12:07am

@gigi2016
Thank you for sharing your story and list of CHEK2 risks. I pray that your biopsy comes back negative. So stressful waiting for results. I also pray your other son is CHEK2 negative.

I am curious why they left your ovaries intact when you have an increased risk for ovarian cancer.

Interesting about your father. Did he have any genetic testing? My grandmother died from stomach cancer. She had a 12 pound tumor when diagnosed! She was petite but thought she was just gaining post-menopausal weight. I wonder if she had the CHEK2 mutation? I know my BRCA2 came from the other side of the family, but not sure where CHEK2 came from.

Please let us know how the biopsy turns out. Let’s all keep up with our screenings. Zebra

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colorado73 | @colorado73 | Mar 10 2:28pm

Thank you for sharing this. I'm so sorry. Yes it's very frustrating for sure to go through the anxiety of being tested & the waiting for the results. I do understand. I finally got through therapy for voice therapy to help from thyroid surgery. That helped a lot. I still see weekly a Occupation Therapy for lymphedema from breast surgery. It truly helps. Being around positive people truly help. God bless you & your son.
Hang in there💕🙏

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