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Vitamin D intake and PSA reduction

Prostate Cancer | Last Active: Mar 10 4:07pm | Replies (14)

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@handera

The two clinical trials, cited in your clip, can be found at these websites:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387395/ (April 2012)
This trial included 44 participants who took 4000 IU of Vitamin D daily for 1 year.
Results:
"No significant changes in PSA levels were observed. However, 24 of 44 subjects (55%) showed a decrease in the number of positive cores or decrease in Gleason score; five subjects (11%) showed no change; 15 subjects (34%) showed an increase in the number of positive cores or Gleason score."

https://academic.oup.com/jcem/article/98/4/1498/2536841? (May 2013)
This trial involved 66 PCa patients scheduled to undergo radical prostatectomy. They were randomly placed into three groups and given vitamin D orally, once per day, for 3 to 8 weeks, up to the day before their RP surgery.
1) 400 IU (10 μg)
2) 10 000 IU (250 μg)
3) 40 000 IU (1000 μg).
Results:
- Groups 2) & 3) had lower blood serum levels of parathyroid hormone (PTH is a measure of PCa bone metastases) and PSA (see baseline/final chart attached).
- "In conclusion, our clinical trial data support the hypothesis that prostatic in vivo vitamin D metabolism can be modulated by high oral vitamin D dosing. Furthermore, the decrease in Ki67 labeling and modest declines in serum PSA and PTH with higher prostate calcitriol achieved with vitamin D doses (10 000 and 40 000 IU/d) suggest a potential clinical benefit. Lastly, the vitamin D doses (400–40 000 IU/d) were well tolerated by PCa patients without signs of toxicity."

Years ago I was found to have a Vitamin D deficiency. I currently take a 5000 IU Vitamin D softgel capsule daily, maybe I should increase that to 10,000 IU/day???

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Replies to "The two clinical trials, cited in your clip, can be found at these websites: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387395/ (April..."

No. It was published here but thank you for adding more information about the subject.
https://bmjopen.bmj.com/content/bmjopen/11/3/e044055.full.pdf

When mine was low my doctor put me on a 50000 dose once a week for 10 weeks. After that my D level was 78, well above the level needed. He said it was safe to be at 100. I take 5000 daily. Good luck.