Vitamin D intake and PSA reduction

I'm not sure if Vit D does reduce PSA. What is definite is that Vit D is given to help protect against bone loss and fractures caused by androgen deprivation therapy (ADT) which is a common treatment for PCa. ADT can lead to accelerated bone loss and fractures and also cause a decrease in bone mineral density. Initially, after a weekly dose, I am now continuously on 60K units every month.

What about increased calcium in your blood?

This is what I’ve read

Interesting. please provide the link to this report, I'm always game for bringing things up to my health team. I concur that Vitamin D and bone density are active in treatment methods.

The two clinical trials, cited in your clip, can be found at these websites:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387395/ (April 2012)
This trial included 44 participants who took 4000 IU of Vitamin D daily for 1 year.
Results:
"No significant changes in PSA levels were observed. However, 24 of 44 subjects (55%) showed a decrease in the number of positive cores or decrease in Gleason score; five subjects (11%) showed no change; 15 subjects (34%) showed an increase in the number of positive cores or Gleason score."

https://academic.oup.com/jcem/article/98/4/1498/2536841? (May 2013)
This trial involved 66 PCa patients scheduled to undergo radical prostatectomy. They were randomly placed into three groups and given vitamin D orally, once per day, for 3 to 8 weeks, up to the day before their RP surgery.
1) 400 IU (10 μg)
2) 10 000 IU (250 μg)
3) 40 000 IU (1000 μg).
Results:
- Groups 2) & 3) had lower blood serum levels of parathyroid hormone (PTH is a measure of PCa bone metastases) and PSA (see baseline/final chart attached).
- "In conclusion, our clinical trial data support the hypothesis that prostatic in vivo vitamin D metabolism can be modulated by high oral vitamin D dosing. Furthermore, the decrease in Ki67 labeling and modest declines in serum PSA and PTH with higher prostate calcitriol achieved with vitamin D doses (10 000 and 40 000 IU/d) suggest a potential clinical benefit. Lastly, the vitamin D doses (400–40 000 IU/d) were well tolerated by PCa patients without signs of toxicity."

Years ago I was found to have a Vitamin D deficiency. I currently take a 5000 IU Vitamin D softgel capsule daily, maybe I should increase that to 10,000 IU/day???

According to clinical trials, the observed effect of Vitamin D on prostate-specific antigen (PSA) reduction is noteworthy. However, it is essential to note that it does not have a significant impact on the Ki-67 index, which holds relevance for prostate tissue, as an elevated Ki-67 index may signal a less favourable prognosis for the disease. Additionally, vigilant monitoring for potential side effects, particularly hypercalcemia, is crucial. To comprehensively understand the positive and negative outcomes associated with a substantial dose of Vitamin D in reducing PSA, further extensive clinical trials are imperative.

No. It was published here but thank you for adding more information about the subject.

It may be that Vitamin D plus Vitamin K help to absorb the calcium into your system. Therefore improving the bone without neccesarily requiring additional calcium intake. Additionally Vitamin D helps the production of T cells which is important to our immuno system. Even though T cells do not normally eliminate cancer cells, recent UK study shows that maintaining a good level of Vitamin D reduces mortality overall, including those with prostate cancer.

Vitamin D3 therapy (50,000-100,000 IU/week) was safe and effective when given for 12 months to reverse statin intolerance in patients with vitamin D deficiency. Serum vitamin D rarely exceeded 100 ng/mL, never reached toxic levels, and there were no significant change in serum calcium or eGFR.

A 2011 report on vitamin D toxicity showed that hypercalcemia resolved when 25-hydroxyvitamin D (25OHD) blood levels dropped below 400ng/ml in 2 patients with blood levels ranging from 645ng/ml to 1220ng/ml after accidental ingestion of massive doses of vitamin D. We now know that vitamin D is made in the skin in amounts ranging up to 25,000 IU a day with exposure to UVB radiation. There is little data on the safety and blood levels of 25OHD and calcium after prolonged daily intake of amounts of vitamin D in this range. In this report, one subject took increasing daily doses of vitamin D3 for 6 years starting in April 2009: 6500 IU for 6 months; increasing to 10,000 IU for 13 months; 20,000 IU for 24 months; 40,000 IU for 12 months; 50,000 IU for 10 months, and 60,000 IU since October 2014. 25OHD blood levels were 28, 81, 204, 216, 225, 166, and 218ng/ml. Subject 2 began 10,000 IU in Nov 2011, increased to 20,000 IU in Feb 2014, 25,000 IU in June 2014, and 30,000 IU in Oct 2014, and then decreased to 20,000 IU in June 2015. 25OHD blood levels were 96.6, 161.1 and 106.9ng/ml. He reported marked clinical improvement in his asthma. Subject 3 started on daily 10,000 IU in Sept 2013, increasing to 20,000 IU on Nov 2013. 25OHD blood levels were 31.4, 102, 164, 148, and 143ng/ml. No one developed hypercalcemia or any adverse events. The major finding of this case series is prolonged daily dosing of vitamin D3 with doses of 10,000 to 60,000 IU was safely tolerated.