I did have some carpal tunnel syndrome from crocheting. I stopped the crochet and the carpal tunnel got even worse. Now I have trouble with my right shoulder. I went off anastrazole after three and a half months and it has been since February 16th that I stopped and astrozole. I think it found my vulnerable spot and and decided to show effects there. If you're taking it it's interesting to notice that a light case of whatever you had before is now doubled or worsened.