Maybe I've forgotten my reading up on preparing for Evenity shots but I just drink more water than usual and I've been fine. I know for Reclast folks are way into Tylenol and other anti inflammatories and slow infusions and saline infusions and so on. Makes me nervous about Reclast but I haven't noticed many people having those same kinds of issues with Evenity. Just saying maybe you don't need that stuff at all.