I did chemo/radiation and surgery August 1, 2023 at Mayo Phoenix and am halfway done with the Opdivo regimen, starting the once a month infusion after 6 months of twice a month. No real side effects except for some joint ache in my legs, probably some arthritis from old football injuries. Doctors are keeping an eye on my thyroid levels. Immunotherapy can make your thyroid lazy. I just turned 70 and had a fairly easy time with all the treatment plans as well. Good luck and stay active.