← Return to Titrating Zonisamide to Lamictal: What side effects to expect?

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Well my decision to take my autistic, nonverbal , epileptic daughter from Zonisamide to Lamictal begins.. her abdominal distention, hospitalization, brought me back to original concern that 25# weight gain, ammonia, kidney values increased first began after Zonisamide initiated so only way to know is change
Question, from 300 to 200 to 150,100 finally to 50 .. dr will start Lamictal at 50 mg week.. then from 25-100 for 4 weeks till lab for Lamictal
Any ideas on this titration schedule?
She hasn't had seizure since 5/2022 on Dilantin..
Also her abdomen still distended.. dx at hospital discharge was bladder infection and fecal impaction, no gi visit yet, waiting!

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Replies to "Well my decision to take my autistic, nonverbal , epileptic daughter from Zonisamide to Lamictal begins....."

My 48 yr old daughter with autism/ epilepsy on Zonisamide for several months, began adding 2# monthly tho dr said not from frug? But she ended up hospitalized with extreme abdominal distention, megacolon and needed enemas, etc.. now on Lactulose and Colace which has helped get impaction cleared a lot but does the megacolon take a long time to shrink? Bein nonverbal is so difficult for her to express pain, discomfort but she was very traumatized from hospital stay so wondering about reversal of megacolon?
Thank you
Maureen Dolman

When Zonisamide titration from 300 down, to 250,then 200.. holding there until Lamictal reaches 100 target dose, then lab for level, can the Zonisamide be completely stopped if Lamictal level acceptable?.

My autistic 48 yr old daughter with epilepsy is titrating down on Zonisamide , was 300,now holding at 200 till Lamictal which has started at 25,now 50 reaches 100 then lab levels but her affect, behavior has changed to becoming very loud, eating rapidly, almost a manic state..Any suggestions? Thanks