I only take 300 mg at bedtime, although it was prescribed for me to take it twice a day. It can cause balance issues and dizziness. Because I drive and am active during the day i decided to try taking it only at bedtime. It took awhile to get bicep pain relief at that dosage but the sleep benefit started right away. It was initially prescribed for nerve pain because my PMR first presented as carpal tunnel but then quickly progressed from there and I was diagnosed and prescribed prednisone.