Any of the A.I pills will inflame arthritic joints. I had to quit after my left knee bkew out Symptom mimicked a meniscus tear. I was in a wheelchair from 9/15/2022 until March of 2023 and had 32 ml of an anti-inflammatory injected and 6 ml of Durolane and took Tramadol for pain (50 mg,) but very sparingly. I was off everything for 9 months, then tried 5 months of Tamoxifen. My side effect on Anastrozole could have been predicted before putting me through it, because I had been one of 3,000 people in a clinical trial called the MOST trial for 20 years, until 2020 but my oncologist, quite frankly, acted like he didn't care if I lived or died,. When I told him of the teariness, excruciating back pain, mood swings, brain fog, vivid violent nightmares, blurry vision, he simply said, "Don't take it then" and got up and walked out of the examining room. No suggestion of alternative pans of action, Wouldn't order me an oncotype ("You don't need one"). When I was literally in a wheelchair, his remark was, "You're just old." He saw me a grand total of 2 times in 8 months and denied that any of the symptoms i suffered with from December of 2021 until 2023 were caused by his prescribing Anastrozole to a women with severe osteoarthritis and 2 damaged joints (left knee and elbow), He did not order any expensive tests,because he "didn't want to get dinged by Medicare" On Tamoxifen, I had exteme fatigue that left me unable to be up for more than 3 hours at a time and non-stop UTI infections. I quit all adjuvant therapy drugs on Aug. 30, 2023. I did have 33 radiation treatments, which I hope will protect me. My Texas oncologist finally got me an oncotype and it was 29. My tumor was 11 mm, 95% estrogen positive, 1A and I was 76 when diagnosed on Pearl Harbor Day in 2021,