I might add that my daughter age 40 has two healthy children and had none of my problems during gestation. As to DES in dogs, there is plenty of documentation of bone marrow dysplasia with the use of DES for incontinence. at higher doses. Again, the recommended doses vs the effective doses can be vastly different and if a patient does not respond to a small dose, it is not safe to increase it without anticipating side effects. Since it is used in spayed dogs for this leakage problem there is little reproductive tract left to be concerned about for cancer formation, but as to other types.......?