@gamaryanne , It will be interesting to compare notes and data points. On my GAC chemo recipe, they reduced the Abraxane by 15% for my two biweekly treatments in January (Gem and Cis still full dose), with slight increases in my CA19-9 each time (from low 40's to low 50's).

In early Feb I had to miss a treatment (because of Covid, on my birthday no less), so it was a 4-week interval before I got infused again. CA19-9 was up to 131 by then, so I restored the full dose of Abraxane for that treatment. Will find out this Friday if that did anything for my levels.

I also had scans last weekend, and results showed growth after consistent shrinkage in the 4 main tumors we track. Not sure if it was due to the Abrax reductions, the missed treatment, new drug resistance, or none/some/all of the above, but I'm scared as hell now to skip or reduce anything.

Also had Tempus testing done (finally) on my Whipple tissue from 1.5 years ago. We knew about my germline ATM mutation from the outset, but Tempus also identified a somatic KRAS G12D mutation that Guardant never picked up from the blood-only test.