Hi friend, I was using ZenWise Advanced Digestive Enzymes with pre and probiotics and got relief using them. I recently bit the bullet and had an endoscopy done that revealed I had a hiatal hernia which I think was the cause of a lot of my discomfort, Having been on the over-the-counter antacids for years, my doc felt they were not doing the job, and put me on a prescription that is working very well. Good luck to you