When I was on Prednisone for my GCA, I split my daily dosage anyway I wanted with no ill effects because I thought I was supposed to. Three 10mg tablets a day I assumed meant one every 8 hours, so that is what I did. I didn't realize that I COULD take it all at one time. After being off Prednisone for 6 months and being put back on it for 6 months prior to switching to Actemra, I just took the entre daily amount at one time. Felt no difference between the two ways.
Actemra worked fine for me for the 90 injectins I took (on each week). No side effects, and it cleared up my GCA to the point I was able to stop taking it after 90 weeks. There has been a slight expected "back slide" after stopping. I now have periods of tiredness during the day similar to the feeling I had prior to taking it. But, my doctors haven't pinpointed the reason. Many things can cause this including poor sleep habits, depression, medical, or other medications. I think I should have continued the Actemra, but at a lower dose. My clotting platelets were creeping lower with the Actemra and I have a touch of thrombocytopenia so that was an added incentive to cease the Actemra. Once off the Actemra, my platelets went back up.