I think that a "mature" (ok...old) woman will react differently to these toxic pills than younger patients, and I cannot quite fathom how this "one size fits all" prescribing is good for my old body. I know that when I tip-toed into the Tamoxifen waters with just 10 mg. every other day, it was bearable. Taking 20 mg. daily was not. However, Tamoxifen is less likely to damage/inflame and otherwise deplete our bone density and mine has been on a steady downward spiral since taking Anastrozole. It was really a crap shoot on whether I could have the dental implant I am currently attempting, because I am also a Type II diabetic and diabetics don't heal as quickly or as well and then there was the issue of my jaw bone strength, thanks to Anastrozole. I asked for "the best oral surgeon in town" and I think I got him. Wish me luck, because this entire dental fiasco is costing $10,000, and that is with insurance that picked up about $2 grand of it. I also lucked out on NOT needing the $2,600 root canal, or it would have been worse, to (a) remove the #4 tooth that split below the gumline (b) put a crown on the #5 tooth (c) put a new filling in the tooth way in the back that had a cavity under a filling. We are only here until mid May and I've been going to the dentist since Dec. 13th and, with luck, will get the implant on April 23 (if healed enough). The cleaning was Nov. 16 back in Illinois, which caused the second tooth to give up the ghost. (If it's not one thing, it's another!) I had to sign many items testifying that I never took the biophosphanates that will damage your jawbone (Boniva, Fossamax, etc.) and I had been prescribed them and had filled them but hesitated to take (yet another) pill with godawful side effects, since my -2.2T was borderline osteoporosis, thanks to old age and Anastrozole.