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@gently

Reclast is generally recommended after Prolia. Some people have adverse reactions to Reclast. Recommendation from a Stanford bone expert.

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"I have prescribed a lot of Reclast (zoledronic acid), which to my knowledge is always administered in an infusion center, and not in a physician's office.My strong recommendation based on my knowledge of bisphosphonates (given that I helped to develop three of them, and treated 13,000 patients in phase 3 trials with them) is to have the infusion center dilute the 5 mg of zoledronic that comes in 100 mL of D5W into 500 mL of NS, and infuse the endodoc recnow 600 mL over 60 minutes. Making the drug more dilute and administering it more slowly significantly improves the renal safety for N-containing bisphosphonates.I also strongly recommend that the infusion nurses give the patient 650 mg of acetaminophen (Tylenol) at the time of the infusion, and that the patient take that same dose with dinner and at bedtime the day of the infusion, with all 3 meals and at bedtime the day after the infusion, and a final (7th) dose of acetaminophen with breakfast the 2nd morning after the infusion. These 8 doses total of Tylenol reduce the chance of a symptomatic APR (Acute Phase Reaction) from 22% to < 1%.Best, endodoc"
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Windyshores convinced her physician to prescribe a half dose. You can access all of her advice on by clicking on her name. I suspect you'll hear from her directly.

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Replies to "Reclast is generally recommended after Prolia. Some people have adverse reactions to Reclast. Recommendation from a..."

I did not convince my doc to reduce the dose. He has been nervous about prescribing Reclast to the extent that he did not prescribe it during my cancer treatment, which is how my bones got so bad.

The concern about afib (I have paroxysmal afib) and kidneys has lessened but he still wants me to do a test dose of 20% (not half). That is 1 mg out of 5mg full dose.

I have done a partial dose of Tymlos and for my second appointment for Evenity, declined the second shot and only did one, which is a half dose. My doc did not prescribe that. I just declined on the spot and messaged him about it.

I have read that 2.5mg (1/2 dose) of Reclast is effective. I plan on asking my doc about that. His plan is for me to do the test dose of 1mg, then report after a month whether I tolerated it and what my next dose should be. I want to emphasize that this arrangement is probably unusual and is related to my other health issues. And it is coming from the doc, not me (for a change!)