Splitting the Prednisone dose seems to be one of the more contentious issues with PMR. Your Dr seems to be taking the hard line on following standard guidelines because your husband has the more serious GCA disease and it could be a liability issue for them if something goes wrong. If you read up on how long Prednisone is active over the 24 hr period, there is a period where its effectiveness drops right off after 12 to 16 hrs which leaves you with pain in the middle of the night. So the argument that an evening dose is going to interfere with sleep is invalid because pain is already doing that ! The real reason it's not a great idea is that apparently there is evidence that you are more likely to suffer long term Adrenal insufficiency. This is also an invalid argument in your case because at 80mg AI is a likelihood anyway. Then there's the diurnal rhythm argument, well our bodies do have a slight uptick in cortisol in the evening and all you are doing with a smaller evening dose than the morning one, is mimicking your body's natural rhythm. Finally, does an evening dose make it harder to reduce when you get to single digits, in my case yes, but is it worth that risk to get a peaceful night..you decide.