Don't know about Zometa, but I am on Prolia (2 yearly injections) for osteoporosis. I have been for 7 years. I recently had a consult with Mayo Endocrinologist for advice on whether I should continue with Prolia or change to a different drug. I have lung cancer and know that some osteoporosis drugs were used in bone cancer. The Mayo specialist told me they usually see women with breast cancer, and they have them on Prolia for 12 years now because of its anti-bone tumor properties. He advised me to continue on Prolia for another 5 years before changing drugs. I am glad I asked the question!