I’ve had osteoarthritis in both knees for years and have been taking Glucosamine (1500mg.) with Chondroitin (1200mg.) since I was diagnosed and it has helped me tremendously. I also walk 5 miles/day and workout with weights. I initially did PT to learn exercises that also helped. I do avoid squats, lunges and anything that puts added strain on my knees and I can say that I have been pain free for years once the inflammation was under control. I also don’t take any otc meds unless absolutely necessary. I hope this helps and you are pain free soon!