← Return to Prolia black box warning?
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Osteoporosis & Bone Health | Last Active: Apr 28 8:56am | Replies (59)
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Replies to "I get that Prolia is a complicated topic as it does have strong benefits but it..."
Hi awfultruth,
I love the member names on this site.
Okay, fair enough. I guess is comes down to the definition of rebound effect. You will lose a significant amount of BMD by stopping Prolia, Evenity, Tymlos or Forteo without follow-on treatment. To your point, I can’t find a study showing fracture rates after stopping the osteoanabolics, but you can find studies showing the sudden loss of BMD (attached for Evenity) https://doi.org/10.1002/jbmr.3452. I do seem to recall there is an increase in fracture rate after stopping the osteoanabolics without treatment but I can’t remember where I saw it.
Now just to be clear, the multiple fractures after stopping Prolia is when patients do not immediately follow treatment with a bisphosphonate like Fosamax or ReClast. You can see the data of fractures after Prolia both with and without follow-on bisphosphonate treatment here https://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbmr.4335. Lot’s of good data in this study on Prolia and breaks.
I put together a Prolia training of sorts and cover the data I have on stopping Prolia and what to expect. If you want to get deep into the weeds, it's posted here https://youtu.be/XiRN3UvOEYg .
Finally, I'm not a doctor. I'm doing research for myself and others to work with their doctors to help achieve the best results. I don't get paid for any of what I do here, I'm just a retired engineer trying to help others.