I have early multicentric lobular breast cancer w/ a positive lymph node but have declined all estrogen blockers, and radiation. I must have reviewed over 500 peer reviewed articles and 50? medical presentations on UT and concluded that the documented adverse effects would ironically increase my risk in other ways. Beyond that, I'm disabled from a connective tissue disorder--getting worse w/ age, and genetic--and so taking it would put me in bed all day to what? Have more years in bed in all day?

Instead of titrating estrogen blocker dose to a woman's weight and any kind of baseline estrogen measurement to at least establish basic efficacy, the same amount is given to someone w/ a BMI of 40 and or 21. Women are told their symptoms aren't real--placebo effect! It's in your head! The depression and fatigue induced by these drugs then preclude exercise & social activities (two major preventative factors for recurrence) and contribute to inevitable weight gain. Excess weight carries excess estrogen and is a known risk factor for recurrence as it promotes metabolic syndrome.

No guidance is given to patients about reducing glucose (carbs, sugar, fruit juice) that feed cancer cells--instead, pasta and whole grain breads are GREAT. It's "Mediterranean"--which remains undefined to this day. No info on intermittent fasting being linked in dose dependent manner w/ lower recurrence in breast cancer (published in 2016) and seen in so many other cancers.

And then pain? In an atmosphere of sadistic undertreatment of pain--especially women's--with even Stage 4 cancer patients being undertreated b/c of an insane hysteria about opioid misuse that was misrepresented from the outset (it was due to illegal drugs, not prescriptions)--estrogen blockers cause DOCUMENTED HARM TO CONNECTIVE TISSUE. At least 600 pubs are on the joint pain caused by these drugs, including many studies using MRI, biological and genetic analysis to demonstrate that YES, damage is being done to these joints because estrogen is so critical to joint health.

So---everyone can make their own choice. If I were naturally resilient, younger and healthy, have young kids, have a great community, no comorbidities, awesome physicians and pain control should I need it, AND, a later stage tumor--I could see using a lower dose. But it's not worth it for me and I've got the citations to stand up to any doctor telling me it is.