Hi! I just completed a round of Tobramycin. All of the manufacturers directions say it is to be used with the Pari LC plus nebulizer and a Pari compressor. However, neither my doc nor the hospital pharmacist (whom I spoke with at length) mentioned anything to me about this. I did use the Pari LC plus nebulizer because I had a new one and I calculated that possibly the medication needed to be delivered a certain way. However, I have an Ombra compressor and just hooked it up to that. The Pari LC nebulizer costs around $15. Maybe call the manufacturer or talk to your doctor or pharmacist to see what they recommend. This was my first diagnosis of Pseudomonas and my culture was negative shortly after the treatment.