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Support For Those Quitting Prolia
Osteoporosis & Bone Health | Last Active: Dec 20, 2024 | Replies (153)Comment receiving replies
About the 'rebound period.' You say that the studies you reviewed show a rebound period of 1 year. In the original post initiating this thread, the rebound period is referenced as 30 months.
That is a significant difference. Would be helpful to know which one is more generally recognized and the source of/authority for that info.
This is an amazing discussion. Thank you.
Replies to "About the 'rebound period.' You say that the studies you reviewed show a rebound period of..."
Maybe i can help to clarify.
I was using T0 (time zero) as the date of the last Prolia injection whereas Michael was likely referring to the 1 year period commencing from 6 months after the last shot (i.e. T6-T18).
Using my definition of T0, most of the fractures occur within the period T6-T18 (or 1 year after the effect of the last Prolia shot wears off) but the rebound risk remains from T18 till T30
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Good point, let me clarify. Attached a slide in the backup of my presentation that I did not have time to discuss. The content came from this study https://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbmr.4335. It has all kinds of nuggets in it.
If you look at the picture, it shows the timing of fractures after stopping Prolia without a bisphosphonate following treatment. It's kind of like cooking popcorn, nothing happens when you press start, then it gets moving pretty good, then it's just a pop once and a while. Perhaps a poor choice of analogies but it fits well.
So yeah, while the study shows out to 30 months, the bulk of the breaks happen in the first 12 to 14 months. And if one did follow Prolia with a bisphosphonate, the feeling is most of the rebound effects would be diminished in about 12 months. That is how I understood the explanation from Dr. Serge Ferrari when I heard it in September 2023.