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Support For Those Quitting Prolia

Osteoporosis & Bone Health | Last Active: 6 days ago | Replies (86)
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@rjd

What is a 'significant risk' of fracture or osteonecrosis?" And how does this risk compare to the risk of fracture without treatment? Numbers would be helpful here, if possible.

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Replies to "What is a 'significant risk' of fracture or osteonecrosis?" And how does this risk compare to..."
formisc | @formisc | Feb 29 7:20pm

Hi rjd,
No, i do not have specific numbers but i did not want to say there was "no" or "little" risk or that there was "high" or "huge" risk - to me, "significant" was the right level. There are several studies showing the link between prolonged use of Prolia (and bisphosphonates) and AFF/ONJ but in the interest of keeping the focus of this thread on "How to quit Prolia?" rather than "Why quit Prolia?", i will post just two of them here:

Long-term consequences of osteoporosis therapy with denosumab
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118828/

Time to onset of bisphosphonate-related osteonecrosis of the jaws: a multicentre retrospective cohort study (2016)
https://pubmed.ncbi.nlm.nih.gov/28039941/

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