@mas0415 The one thing that my GI doctor was able to do for me that helped my IBS-D was Rx a boutique antibiotic that does not go into your blood stream but stays in the GI system. He Dx Small Intestine Bacterial Overload (SIBO). Once I took the Xifaxin my IBS episodes went from every 5-7 days to every 3 weeks. The drug is very expensive and I had to get it from Canada because my drug insurance just does not do well with high priced boutique drugs. It was worth every penny I spent. It was a gamble since IBSO is not easy to positively diagnose. He ran the test and I came back normal, but he went with his intuition and experience.
I wish you success on your journey.