Anyone on Pluvicto (Lu 177), a new drug for prostate cancer?

Posted by dedehans @dedehans, Aug 20, 2022

My close friend has had Pluvecto treatment suggested to him by oncologists. It is relatively new, having been approved by the FDA in March 2022. Have any of you been given this drug? I have read it is radioactive material and patient needs to stay away 6 ft from others for at least 3 days so as not to contaminate them. He has not yet decided whether to take the treatment or not as he is feeling awful enough as is.

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kbrz | @kbrz | Feb 27 9:46am

Received Pluvicto #3 this morning. No apparent side effects from #1 or #2. I was on Chemo (3 doses) and could feel the battle within; since changing to Pluvicto I have returned to myself, in most respects. We each react differently, but this has given me back an active life. Bloodwork after #2 showed lower PSA; 2.3 from 10.6. Bloodwork between #1 and #2 had PSA nearly unchanged. Original diagnoses Jan 2016, removal May 2016, 35 days of radiation July/Aug 2016.

morlyn | @morlyn | Sep 8 11:15pm

My husband completed his Pluvicto 2 months ago. The dry mouth is still severe. Has anyone had the saliva return?

melcanada | @melcanada | Sep 9 6:25am

In reply to @morlyn "My husband completed his Pluvicto 2 months ago. The dry mouth is still severe. Has anyone..." + (show)

Bye https://smartmouth.com/blog/xylitol-mi…
https://smartmouth.com/blog/xylitol-mints-dry-mouth/
XylitolMints Help Relieve Dry Mouth - Smart Mouthtabs at drug store 2 for one Put in mouth at night

Colgate makes a dry moth tooth past Then biotin

lag | @lag | Sep 9 8:20am

In reply to @morlyn "My husband completed his Pluvicto 2 months ago. The dry mouth is still severe. Has anyone..." + (show)

Hard candy or mints with xylitol help. Haven't tried the Biotin yet but it was also recommended at Mayo Rochester.

melcanada | @melcanada | Sep 9 9:52am

In reply to @melcanada "Bye https://smartmouth.com/blog/xylitol-mi… https://smartmouth.com/blog/xylitol-mints-dry-mouth/ XylitolMints Help Relieve Dry Mouth - Smart Mouthtabs at drug store 2 for..." + (show)

https://www.drugs.com/mtm/xylimelts.html and CVS work great

melcanada | @melcanada | Sep 10 6:05am

In reply to @lag "Hard candy or mints with xylitol help. Haven't tried the Biotin yet but it was also..." + (show)

Xylimelts XyliMelts Adhering Pastilles Mild Mint Falvour at CVS XYILOMELTS

morlyn | @morlyn | Sep 11 9:33am

In reply to @melcanada "Xylimelts XyliMelts Adhering Pastilles Mild Mint Falvour at CVS XYILOMELTS" + (show)

Thank you to all. He has tried a number of mints / candies with and without xylitol, sprays, washes, nothing seems to help. We are more interested in..,.if you had Pluvicto and lost all saliva - did it ever return (saliva) or once its gone is it gone forever. Can't seem to find a study that says and doctors/techs don't seem to know either, THANK you

melcanada | @melcanada | Sep 11 11:02am

In reply to @morlyn "Thank you to all. He has tried a number of mints / candies with and without..." + (show)

Colgate has a saliva generating tooth paste

melcanada | @melcanada | Sep 11 12:50pm

In reply to @morlyn "Thank you to all. He has tried a number of mints / candies with and without..." + (show)

Beware Parenditis blockage ER for med if it happens

Two Xylomelts should work

round5 | @round5 | Sep 12 6:04am

PSMA Scan Impression from yesterday after completing all 6 doses of Pluvicto in April:

Reduced metastatic disease uptake with probable persistent low-level disease in a left lower neck node and left axillary lymph node. miPSMA Expression Score: 2

It might also be noted that I received 6 doses of Docetaxel and Carboplatin chemotherapy right before the Pluvicto. I completed everything in a 1 year period. I am still on Leuprolide and Darolutamide and my PSA is undetectable.

Appointment with Dr.Kwon this morning.