I have had peripheral polyneuropathy for 12+ years. No pain ever, but increasing numbness/weakness/leg fatigure/balance issues, beginning at feet and now up to knees. Hematology specialist MD diagnosed me with lgM MGUS (Monoclonal Gammapthy), which he thinks might have contributed to my neuropathy. He offered Rituximab infusions as possibly helping with neuropathy, but only in 30% of treatments and that could be months or a year hefore see any improvement, if do see any. I did two sets of 4-infusions each. He said to return in a year (April 2024) and see if any neuropathy improvement. After 10 mths since last infusion, I have not seen any improvements, and actually leg numbness/fatigue/balance has advanced further up to my knees. Would be interested in learning if anyone has had these infusions and seen any improvement.