Thank you @emo. I took your advice and tried to find out if it was a safety or evidence reason and got the run-around. My question wasn't answered. I think it's her having one flat answer and maybe she has her reasons. However, yesterday I spoke with a nurse after getting so frustrated with so many aspects of what's happened since he developed GCA. It's been a ride. I finally decided to ask for a 2nd opinion and the rheumatology department seemed to take offense to that. I was told they would not approve the request because it was outside our insurance, however, the doctor we want takes our insurance. Regardless, they knew I was at my wit's end with no good solutions. Basically we were being told by his doctor if he gets a headache during business hours to go to the lab for CRP & ESR levels while I call the doctor. Well, calling the doctor is no easy undertaking and takes time. If after hours, go to the ER. With an upcoming weekend I was frustrated and told the nurse that we need a better treatment plan going forward and that I found this unsustainable. Since when he takes the 80 mg all at once he will wake up with a headache around 6 am and under her orders we'd be in the ER every day. We felt there had to be another solution. She really listened and said she would talk to the doctor who was available, that ours was out until next week. It so happened she was able to discuss it with the Chief of Rheumatology who came back with a completely different approach to dosing, one we feel is appropriate for my husband. She said take 80 mg within 24 hours. We can split it 40 mg in AM 40 mg in PM or any way that works for him, so long as he gets the full 80 mg within the 24 hours. She also completely contradicted our doctor who said to take the full 80 mg in the morning when she said 80 mg is too high a dose to take all at once. My Lord this has been frustrating. We did it our way and he woke up pain free and is one happy man today. Relieved for sure.