No, you are not crazy. It isn't "you". Sometimes it isn't even the doctors. I posted months ago now, about finally being diagnosed with Serum Negative RA. Three years ago. He was a rheumatologist, he was just the best. After so many years of the revolving doctors who also get frustrated, I could not believe what he was telling me. He was much younger, not that matters, but I think it may help. He also was personable. He told me, that too many doctors rely only upon lab tests. He said you limit your patient's when you do that and you are not fair to them. I saw him for one year. I started the long road to better health. You always have to start at the beginning with the drugs. So, Methotrexate was up. It helped my energy level which was so poor. As you all know, autoimmune diseases, no matter what they are, sap you until you cannot move. Then, he resigned from that practice and moved. UTSW is a long painful and difficult trip for me. I can't drive, which means getting Medicare transportation. So, I stayed with that group and went to another rheumatologist. She was just terrible. She did not believe I had RA. She gave me Meloxicam, which I had years before etc. Anyway, I called his new office and it took me six months to get in. In that time, my knees, which had never hurt, became agonizing. It crippled me. By the time I saw him in July 2023, he didn't even bother with anything else and put me on Humira injections. My brother takes them for Psoriasis, and claims they did not work. That isn't true, FYI, because he cleared up. It does take a while but by the fourth injection, I could walk. And that was without pain. That was at Thanksgiving. He did repeat blood work, and it was the same. My hands were becoming deformed and they and my feet were bothering me more. But my knees had just ruined my life. So, here is the thing. After injection six, I noticed I was sliding backward. My hands and feet were worse, my jaw, where I have one arthritic joint was very painful, and my energy level went downhill. I was laying in bed all day on some days. Something I had never done. Well, this same great doctor, resigned from THAT practice and went to do clinical trials. My knees, although not as painful, I knew had to at least do something about that so I went to an orthopedic doctor. He was concerned about my other issues and also told me both knees needed to be replaced. He recommended a friend of his who was a Rheumatologist. So, I thought, sure, why not? He called him personally and asked him if he would see me. So, two weeks later, I went to see Dr. Cohen at Christus Mother Francis in Tyler, Texas. He was much older, but he did not miss a thing. He read my entire history printed it off to study, and asked me everything. I told him things I was having problems with I had never told anyone. So, he took a lot of blood. Those 28 tests you mentioned. It was the first time I had ever had those tests run. Ever. By anybody. It took ten days to get the results, including a weekend. And I do read all my tests and doctors' notes. Always. And, was I shocked? I have Lupus. And I have the RA in my hands and my feet and my knees and ......Do you know what the Lupus Foundation of America calls Lupus? The cruel mystery. They use purple ribbons. Now, I am 72. How long have I had it? Who knows? My guess is from the time I was in my late thirties. I remember the pain and all the medicines and struggling to work and all the side effects. I thought I was crazy. It couldn't all be aging. I am not saying that is what you have, only a doctor can tell you. But don't stop asking. Talk to them about all the autoimmune diseases. Lupus, there are different kinds. And, btw, I never had the butterfly rash they look for. But my skin cannot take the sun. I just bought a book entitled The Lupus Encyclopedia. And in his preface, the doctor talks about the terrible challenge for doctors and patients. Not everybody has the same thing. And some women were borderline. But they take meds. I hope, really, any of this helps.