Interesting verbiage for use of the word phrase; "quality of life"? I am 75, diagnosed with CML Leukemia since 2004 and medicated with Imatinib, formerly Gleevec by Novartis, dropped now to 5 days per week due to anemic lacking of red blood cell count. I am well acquainted with this chemo med and how to deal with side effects, so was living a very productive, active working, always busy life style, until a couple of months ago when hit overnight with PMR crippling both shoulders, swelling of hands, wrists, elbows and fingers. Over the past five years or so I have had 3 failed Lumbar, Laminectomy surgeries that constantly reminded me of what a 10 was on pain scale, until a bit more than a year ago, was gifted with an Abbott Spinal Stimulator Implant that essentially remedied the back pain. The CML and Lumbar is a Piece of Cake compared to this PMR issue! Getting to see a Rheumatologist for me is a wish never granted to date. For these reasons, with help from a GPMD I take Prednisone, starting does at 30mg, which eliminated my pain within 3-7 hrs. the first day. I reduced from 30 to 25, 20 to 15, 15 to 12.5mg per day currently but still suffer extreme Lethargic, Energy-less days from the time of wake-up to about 7 P.M. nursing the pain when bad with Tramadol 50-100 mg. I exercise as much as possible on my treadmill and stationary bike, not comparable to what was prior daily habits before PMR. I have discovered that taking my Prednisone at 5 A.M. to the latest time at 6 A.M. is a huge difference for decreasing the lack of energy, along with getting less sleep of only about five hours max. It is too early to tell for me, but it seems the lesser dose of Prednisone is better for me so far? I am aware of self medicating is incorrect, but have no assistance with proper medical advisors, so just do what feels right for my body and mind, in order to return to my busy and productive self and finish some projects. These conversations I have read are helpful and informative. Thanks to everybody for that, along with my sorrow of your discomforts.