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Trimix injection good or bad idea?
Prostate Cancer | Last Active: Oct 28 5:05pm | Replies (101)Comment receiving replies
So far since starting 11 days ago I'm 2 and 2. At 25 units and 30 units on the right side, I only experienced about 40% erect which was insufficient for sex. At 35 units and 35 units on the left side I had a full erection and it was great. The first time on 35, I was still fully erect at 3 hours so took 30mg of Sudafed and a hot shower, which worked. The second time on 35 I took a hot shower at 90 minutes and still standing firm.
SO my questions to the group are:
1. Do you find that small increments in your dosing have dramatic results? In other words, can bumping up to 30 be effective without the 3 hours of discomfort?
2. Any other strategies for reversing the effect? I have tried the hot shower but not exercise yet. I'm reluctant to push too much Sudafed because of the adverse effect on BP -- with pure autonomic failure I typically have orthostatic hypotension (low BP when standing) and supine hypertension (high BP when lying down) so I have to be careful about taking it at bedtime.
3. Have you noticed any difference in effectiveness when injecting the left side versus right side?
I'm really early into this therapy and testing what works and does not.
Replies to "So far since starting 11 days ago I'm 2 and 2. At 25 units and 30..."
KCar I do have discomfort after injection but gets better after sex is started. After sex discomfort again but cold shower then recline in recliner helps with discomfort and helps errection go down a little faster and usually 60 to 90 minute errection. Have had 2 hour sometimes. 32 units is my favorite not 30 and not 35. A few units does make a difference to me. Injection on right side is usually less discomfort but I alternate anyway.
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My answers to your questions:
1) Effect of small increments in dosing? Yes, dosing matters. That's why I track it closely. My MD started me on 20 units, but by tapering that I got erections that last more appropriately (I keep it in the 45-90 minute range.)
2) Strategies for reversal? The sudafed has worked for me. I note in my chart when I've used it and usually make a dosage adjustment for the next time based on that. I also remain at rest for a period of time, usually one to two hours, less if I am comfortable moving sooner.
3) Difference between sides? I probably have too much OCD, but I use my chart to alternate sides and locations. I have 12 guidepoints--1,2,3, and 9, 10, 11 where 12 is vertical on a virtual clockface, at 2 or 3 finger widths above the base. I do notice some difference between locations and there have been a few occasions where I have "missed the mark". Missing the mark probably means it did not go into the "Corpus cavernosum smooth muscle (CCSM)", perhaps do to a bent needle, diverted insertion, or even a fibroid mass. When the mark is missed I sometimes note a longer but much more mild effect, so perhaps the drugs are arriving but not in the timing and dosage required for effective erectile function. Because of the small number of misses and the variety of positions for insertion, I have not noted a particular pattern.
4) Bonus question: Indicators dose is high? In addition to duration (which I measure to 50% decline, not total deflation,) I notice that higher doses are associated with more pain and sensitivity at the tip. I have not noted discussion of this anywhere or by anyone. Erectile Hardness Scale: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475665/ https://www.drlove.com.au/wp-content/uploads/2020/12/erection-hardness-score-new.pdf [I actually use a 1-10 scale where 10 is max and 0 is nada, with 6 being the minimum required for penetration. I aim for 7-9 combined med + stimulation. Initially stimulation contributed nothing but over time that has increased but still not enough for penetration in my case.]