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Evenity - My Email to FDA

Osteoporosis & Bone Health | Last Active: Sep 23 4:11pm | Replies (73)
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@normahorn

Since Evenity stays in the body for something like 64 days, not the 2 days the NP told me, I wonder if taking the full dose the first time is contributing to the effect experienced after the partial second dose.

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Replies to "Since Evenity stays in the body for something like 64 days, not the 2 days the..."
windyshores | @windyshores | Feb 24 7:11pm

I thought of that. I am considering alternating. Then again, I am considering not doing any more because both my P1NP and my CTX are so low.

Half life is 12.8 days after three doses. Peak is 2-7 days with the average being 5 days.

With that half-life, I would think about 1/32 of the dose is present at day 64. Biological half life may be different from plasma half life though.

After 5 weeks (the space between my doses) I would expect about 1/8 or a little more still to be active in plasma.

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