The usual recommended dose of alpha lipoic acid is 600 mg per day. For acetyl-L-carnitine 500 mg per day and/or prpionyl-L-carnitine 1000 to 2000 mg per day. I take both as they have somewhat different pharmacokinetics, one possibly more effective for cardio, the other more effective for neuro. Some evidence they have synergies. You have to take them a couple months or more before expecting any noticeable benefit. I do think they have helped me a bit. Don't forget your B12 and D3.