I am going to try two shots again next week. One shot is 10% effective and two shots is 16% effective as I remember. Both docs accept my taking a half dose but hope I can do two. Effectiveness goes up with the dose so maybe we small folks are at an advantage. One study said side effects are the same with all doses, or seemed to be saying that. I will report back on that after doing two shots, one shot, then two shots. Doing shots in the thigh slows absorption and my immediate reaction was much better than tummy shots.