@ellerbracke I took the full 2.5mg every day for 5 years. My doc was okay with a half dose but I continued on the full dose. I would love info on whether reducing dose even makes a difference in terms of side effects because effectiveness depends on suppressing estrogen, regardless of dose, and that is what causes side effects. So whether 1.25mg or 2.5mg or even 0.5mg I would think the side effects would be the same. But I don't know.