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← Return to Letrozole: When will I start feeling/seeing side effects?
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Letrozole: When will I start feeling/seeing side effects?
Breast Cancer | Last Active: May 19 10:48pm | Replies (145)Comment receiving replies
I want to thank everyone for their comments. I've taken Letrozole now for almost 3 years, with no major side effects at all. From time to time I have some joint or muscle pain, but with stenosis, sciatica, piriformis issues, and overdoing it with yard work, that may be totally unrelated.
However, I just checked my prescription bottle, and saw that I am on 2.5 mg once every day. I will look into research on this, and discuss the dosage with my oncologist during my next visit.
Replies to "I want to thank everyone for their comments. I've taken Letrozole now for almost 3 years,..."
I did my research on letrozole. And the 2.5 mg is the standard dosage. Didn't matter if your 200 lbs or 100 lbs, 20 years old or 100 years old. The half life is around 48 hours so it is possible (just my thought) that a person could take it once every 48 hours and you would still have 50 percent of the medication in your system. If you don't take it at all the medication lasts in your system up to a week. So🤷. I wonder if they have done any studies on this dosaging. I don't know why there are not more options on this.
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@ellerbracke I took the full 2.5mg every day for 5 years. My doc was okay with a half dose but I continued on the full dose. I would love info on whether reducing dose even makes a difference in terms of side effects because effectiveness depends on suppressing estrogen, regardless of dose, and that is what causes side effects. So whether 1.25mg or 2.5mg or even 0.5mg I would think the side effects would be the same. But I don't know.