Good evening @alknapp and welcome to Connect. You have started a new discussion about what might be the best follow-up to Tymlos. I am glad to see that @windyshores has jumped right in to help you. And now I will try to help you by relaying my positive post-Tymlos experience.

After two successful years with Tymlos, my endocrinologist told me that the only option for me upon completion of Tymlos was Prolia. I didn't know enough at the time to dig in and do my own research. So I had twoProlia injections in the first year. After the first injection, I began to struggle with jaw pain. I kept a calendar that tracked the pain level and the number of days it lasted. At the same time, I started doing some research right here on Connect. Fortunately, my PCP recognized my struggle with Prolia and helped me secure a consultation with Dr. Wermers, an Endocrinologist at the Mayo Clinic.

The solution was to begin a weekly tablet of Alendronate (Fosamax) on the day that I was scheduled for my next injection of Prolia. This decision reduced the half-life amount of medication that was in my body. Some of us just don't have the ability to handle injections that last 6 months.

Suffice it to say, I will have completed 2 years of Alendronate this summer without any side effects. Then it will be time for a Dexa scan and I will know how well this medication maintained the bone that Tymlos built for me as well as the rest of the bone in my body.

Good luck with your decision. Please know that I am here for you.

May you be safe, protected, and free from inner and outer harm.
Chris