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Small fiber neuropathy?

Neuropathy | Last Active: May 31 9:23am | Replies (98)

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@mdamiani57

I've had nephropathy for a few years I was taking B12 sublingual 5,000mcg for years had numbness in feet gradually up to my hips. Then had my doctor test me for B vitamins and they were high both B6 and B12 so after getting a DNA test they said I lack the enzyme needed to process B vitamins after I started taking L-Folate the metabolically processed Folate that converts the B vitamins in the body and stopped taking the high dose of B12 I'm feeling better less numbness but still there but the skin peeling on my hands went away so that and other things were caused by B12 toxicity which has the same symptoms as low B12 which was why I was taking the B12 but I guess without the enzyme it won't process in the stomach go figure.

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Replies to "I've had nephropathy for a few years I was taking B12 sublingual 5,000mcg for years had..."

I'm glad you were able to figure it out. Something similar happened to me with B6, but I didn't know about B12 toxicity.

I think I remember being told that excess B12 just goes out of your body with urine so toxicity isn't usually a concern, but I guess you're right and without the enzyme to help your body process it you could easily fall behind when taking a supplement.

Excess B6 is more well-known for causing the same symptoms as low B12. In my situation, my neuropathy had improved and then slowly started getting worse and we didn't know why. When my B levels were tested, my B6 was high, though I wasn't knowingly supplementing. It turned out I was drinking one daily Liquid IV (the electrolyte supplement) because I have POTS, and electrolyte supplements are one way to manage the symptoms. Liquid IV is supplemented with B12 and B6, and I didn't even know it. It's 140% the recommended daily value. Thankfully, I switched electrolyte supplements, and my neuropathy went back to baseline.

Now, one of my pet peeves (as someone who needs to use electrolyte/hydration supplements daily) is the proliferation of all the different formulations that have all this extra stuff in it and artificial sugar when the WHO formulation for an oral rehydration solution requires real sugar and doesn't require the extra vitamins/minerals. But that's an argument for another post >_

I’m glad the doctor ordered the appropriate test to determine the cause of the problem before throwing more meds at the situation! Feel better.