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Initial blood tests to ask for ?
Osteoporosis & Bone Health | Last Active: Mar 11 5:27am | Replies (54)Comment receiving replies
@mayblin I would like to see that study. Dr. Leder's chart in his video shows the highest P1NP during the first month. I have done one set of two injections, and one injection for the second month. Next appointment is next week.
Replies to "@mayblin I would like to see that study. Dr. Leder's chart in his video shows the..."
I haven't watched Leder's video. If he has a monthly p1np charting, you could just go by that. It seems that evenity has a non-linear pharmacokinetics. Combined with individual variation in respond to evenity, peak p1np might be hard to 'catch' during first 3 months period. In addition, the assumption that p1np peaks at the same time as Cmax has to be made. But, if Leder shows p1np pattern, I think you could apply his method to time your blood drawing.
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@windyshores here it is:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809324/#:~:text=Romosozumab%20exhibits%20nonlinear%20pharmacokinetics.,relative%20to%20the%20given%20dose.
This is not an article for phase I study per se, rather, a summary or a review of evenity's clinical findings from various trials. The numbers that I quoted are in table 2, top line. The other phase I size is very small. You may find the remaining summary, especially 2 bigger phase III data useful to you too.