Hi @windyshores I read that for evenity, the steady state is reached at 3 mo. There was a phase 1 study showed that at end of 3mo, the bone marker p1np showed increase. Also at the end of 3mo, bmd increased 5.3% in L spine and 2.3% at total hip with statistical significance in 785 subjects. You will have a few more shots, right? Your p1np might show a change after 3 mo.