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Has anyone tried the medication leflunomide?
Polymyalgia Rheumatica (PMR) | Last Active: May 16 3:48pm | Replies (46)Comment receiving replies
Thanks for your input. I was on Prednisone and Methotrexate and was able to finally get off Prednisone. What symptoms did you have? I have lost 25 pounds in a matter of a few weeks. I have finally stabilized at 115 pounds, which is worrisome if I lose anymore. Which weight loss is one of the symptoms. Also, I am prone to bronchitis and pneumonia which are also mentioned in the symptoms. Blood pressure is another symptom that goes against me. I actually feel real well with what I am on now. I go see my Rheumatologist tomorrow and will be asking why she is persistent for me to take the Leflunomide.
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As I am at 20 months of taking prednisone, and only 4 and a half weeks in on the leflunomide, I can't really say if I will experience more side effects at this point. I have overcome afternoon nausea and AM headaches that occured at about week one but subsides by week 3. I did not feel any change until about week 3 and a half of the leflunomide. But the decrease in my pain and swelling has been profound this past week. I anticipate further improvement as leflunomide is a long term medication that takes 4-6 weeks to become effective with 3 months showing the full potential. (As per my rheumatologist) at this point I am remaining hopeful.
If you feel well at this time I would certainly discuss this with your rheumatologist. I have not tried methotrexate, but I understand it is the preferred drug of choice and has good outcomes also. I was limited as to my options.
I will be interested as to the reasoning for the switch, yes, given the reported adverse reactions to LF. I have lost weight also, but try to make good food choices, increased protein and I stay active.
All the best to you.