Hello, I am newly diagnosed and have had a similar experience with prednisone. I started at 15 mg and two weeks later was at 40. After each increase I would feel good for 2-3 days, then the pain would return. Finally on 40 mg my sed rate was near normal (31 down from 77), and I was pain-free for a week. My rheumatologist lowered me back down to 30, and again I am having some morning pain. Prednisone dosing is like a “dance”, forward a few steps and back a few. Good luck to your husband! He is lucky to have your support!