I had positive experiences with Reclast. I had five infusions (2011-15) for the first round of meds. After that, from what I can put together, I've had two or three additional infusions. It is now known that the drug remains in the body for quite some time and an annual dose isn't always required. I have been on a drug holiday since 2021.

I always drank 1/2 liter of water before the treatment, and another one after. For the first dose, I went to an infusion center associated with a hospital. The nurses were very kind and considerate - they gave me orange juice, water, granola bars, a television, blanket and a comfy recliner chair :). The nurse also suggested a Tylenol prior to the infusion as a prophylactic which I chose to forego.

My plan is to go back to Reclast after my last dose of Evenity in July, mostly because of the positive experience in the past. So, I guess the short answer is "no side effects". I also like the fact that it's once a year and out of mind. Hope this helps.