I can't speak to the vaccine, but I did ask my oncologist last week about Nalirifox. FYI, I'm currently on a reduced dose of Folfiri (no oxaliplatin). My MD does not like the liposomal irinotecan, which he says has many more side effects than the regular irinotecan. He also said the Nalirifox regimen is more expensive than Folfirinox. So we agreed that I'll stay with what I'm doing now. I'm responding well, so I'm fine with that. As I noted elsewhere on this board, it seems like every MD has an opinion about everything when it comes to pancan. And I'm not any sort of medical professional, just a patient. So I would urge you to take these comments with a grain of salt; they could certainly guide you to ask more questions of your MD, but don't necessarily take them as gospel until you discuss them.