Yes and no, occas when I put a patch on the top of my foot it leaves a red rectangular spot where it was.
I usually need the patches on the side of my foot which covers the bottom and the top side of my foot, and I don’t get any irritation there.
When I was usui g the CBD ointment and the patch together, I definitely got an irritation, so my doc told me not to use both together, and I’ve been ok.