I was grateful for Tymlos. My spine went from -3.7 to -2.5, If the full dose is too much, you can start with a lower dose and ramp up so your body gets used to it. I believe it is most effective for trabecular bone but not sure if wrist is trabecular or cortical. The endocrinologist would know so they probably feel it will help even if it is cortical. My hip (cortical) also improved, from -3.3 p -2.9.