I started Tymlos in November 2022. At first, I had “jolting” back and leg pains that lasted a few minutes. By February, 2023, I had so many debilitating issues (two trips to the ER, spine specialist visit, pain management doc, cardiologist, gastroenterologist, PT) chest pain, rapid heart beat - 135, random stabbing pains in my ankles, constant nausea, severe back/side/shoulder pains, and GERD, perhaps caused by the amount of Tylenol/Advil I used for pain . . . the location of pain changed by the hour and day. In July, I stopped taking Tymlos and the pains began to subside within days to weeks.

I had my first Evenity injections in August, 2023; seven doses down and what a difference! For me, the biggest problems with Evenity are redness, swelling, and pain at the injection sites (like a flu shot) that can last for several days - my last shots did not cause any problems, perhaps due to the nurse letting the meds warm up a bit. Overall the injections sting a bit, but nothing out of the ordinary.

I plan to take Reclast after Evenity, but I’ll be doing more research beforehand. I was unable to take oral meds because they upset my stomach so I started Reclast infusions in 2011 and had four more in consecutive years. My Rheumatologist told me that Reclast remains in ones system for “years” so I was able to skip a few years without any treatment. I had no bad reactions to Reclast, however, I do drink a bottle of water before and after each infusion. Check with your doc and/or infusion nurse about taking a prophylactic dose of Tylenol before the treatment.

I’ve had four vertebral fractures since 2017 - my last DEXA was in January 2024 and my current lumbar T-score is -1.0, so yay for me! Of note: I take calcium, vitamin D and magnesium religiously and walk two miles every chance I get. Unfortunately, I can’t really report on which med made the significant improvement in my lumbar numbers.

My biggest problem now is that I have an infected molar. I am reluctant to have the tooth extracted because I am terrified of developing osteonecrosis. I’ll be working on a treatment plan to avoid having the tooth pulled. If possible, address any dental issues that require an invasive procedure before starting any osteoporosis med.

Please do your homework and talk to healthcare professionals about your treatment. I see far too many posts on users groups that are just plain bad information from people who have no medical knowledge about the drugs they are taking (i.e., advising Tymlos users to take 1/2 dose or skip/stop doses for a couple of weeks without the counsel of a doc).

These are my thoughts and experiences only, yours might/will be different. Best to all of you, whatever treatment you choose.